Programme 2018-02-20T18:56:30+00:00

Scientific Programme

Thursday, November 1, 2018

Fertility Preservation Hands-On Workshop
Director – Dror Meirow
Preregistration needed
Welcome Reception

Friday, November 2, 2018

Session 1: On the forefront of human oocyte biology: Aging, bioenergetics, and epigenetics
Much more than the spindle: a new perspective on cytoplasmic maturation
Comparative biology of oocyte aging
Testing the potential of in vitro grown oocytes
Primordial follicle recruitment and saving ovarian reserve
Coffee Break
Session 2: Gamete reconstruction
Disorganization of the germ cell pool leads to primary ovarian insufficiency
Genome editing reveals a role for OCT4 in human embryogenesis
Direct gamete differentiation from somatic cells?
Gamete reconstitution in vitro
Lunch Break
Session 3: DNA recombination during early embryo development
Impact of assisted reproduction on genomic imprinting
Advances in understanding the mechanisms regulating human oocyte activation and growth
Activated ovarian endothelial cells promote early follicular development and survival
Session 4: Controlled ovarian hyperstimulation: new drugs, new technologies to whom?
New forms of drugs:
1. Long acting FSH.
2. FSH Biosimilars and the new recombinant FSH.
3. SC and Oral progestin

New protocols:
1. Minimal number of injections protocol.
2. Progesterone use to block LH surge. No routine antagonist
3. Flexibility in starting ovarian stimulation.
4. Double ovarian stimulation.

Coffee Break
Session 5: Debate: The use of CRISPR-Cas9 technology in human embryos
Introduction: CRISPR Cas9.
For: CRISPR Cas9
Ethics: CRISPR-Cas9 and the Ban on Human Germline Editing

Saturday, November 3, 2018

Session 6: Implantation and luteal support
How do we choose the best progesterone to support the luteal phase
Chronic endometritis and endometriosis: how these two combine for altering endometrial receptivity?”
Four simple rules that are sufficient to generate the mammalian blastocyst
Coffee Break
Session 7: Fertility preservation: oocytes, embryo and ovarian tissue
The production of ovarian organoids from somatic and putative germ line stem cells in vitro
Single center success in freezing ovarian tissue. How we overcome the various obstacles
Critical overview of egg freezing methods
First clinical results of capacitation culture preceding in vitro maturation of human oocytes from small antral follicles in PCOS
Lunch Break
Session 8: 40 years of IVF: Best practice with respect to outcome, based on accumulated outcome results
Open discussion on:
Insemination parameters (Minimum number based on what parameters)
DAY 2,3,4,,6 Transfer
Best embryo culture systems
Time-lapse vs. timed-static imaging
Through where PGS is truly needed and in which cases clearly improves outcome
All ICSI vs conventional IVF: Why and When
Advances in understanding the mechanisms regulating human oocyte activation and growth
Activated ovarian endothelial cells promote early follicular development and survival
Coffee Break
Session 9: The embryo
Hormonal Regulation of Embryo Transport
Nuclear transfer: Clinical Applications
New challenges of mitochondria research in ART
Nucleic acids and embryo viability